Mitochondrial Dysfunction in the Inflammatory Process of Neurodegenerative Diseases - PubMed
7 hours ago
- #mitochondrial dysfunction
- #neuroinflammation
- #neurodegenerative diseases
- Mitochondrial dysfunction in neurodegenerative diseases involves impaired oxidative phosphorylation, leading to chronic inflammation.
- Complex I defects can cause over-reduced CoQ pools, increased electron leak, and elevated ROS, with supercomplex plasticity affecting ROS propensity.
- Excess ROS damages lipids and mtDNA, releasing mitochondrial DAMPs that activate NLRP3, cGAS-STING, and TLR9 pathways, creating feedback loops with neuroinflammation.
- Evidence from models of Parkinson's, Alzheimer's, ALS, and Huntington's disease supports therapeutic targeting of ETC support, supercomplex stabilization, and inflammatory pathways.