CLIM-TIME links genetic cancer drivers to immune landscapes - PubMed
5 days ago
- #immunotherapy
- #cancer
- #CRISPR
- CLIM-TIME is a spatially resolved in vivo CRISPR screening platform.
- It links the loss of tumor suppressor genes to distinct metastatic immune architectures.
- The platform helps understand divergent responses to immunotherapy.
- Immunotherapy resistance is associated with immune-privileged microenvironments.
- The study was published in Cell by Wang et al.
- The authors declare no competing interests.