Indole-3-Lactic Acid Attenuates IMQ-Induced Psoriasiform Dermatitis in Mice via AhR-Dependent Suppression of IL-17A - PubMed
10 hours ago
- #Microbiome
- #Psoriasis
- #Aryl Hydrocarbon Receptor
- Indole-3-lactic acid (ILA), a microbiota-derived tryptophan metabolite, attenuates psoriasiform dermatitis in mice.
- ILA reduces disease severity, epidermal proliferation, and neutrophil infiltration by suppressing IL-17A production via the aryl hydrocarbon receptor (AhR).
- Topical ILA outperforms benvitimod, an approved synthetic AhR agonist, in alleviating skin inflammation in an imiquimod-induced mouse model.
- The protective effects of ILA are AhR-dependent, as shown by reversal with an AhR antagonist, CH-223191.
- ILA selectively inhibits IL-17A production by γδ T cells, and Lactobacillus reuteri supplementation improves symptoms by increasing ILA levels.
- Public transcriptomic data indicate elevated AhR expression in psoriatic T cells, correlating with IL-17A/F, supporting an ILA-AhR axis as a therapeutic target for psoriasis.