Matrine improves bile acid metabolism and reduces inflammatory and oxidative stress in colitis via the JAK2 pathway - PubMed
4 hours ago
- #JAK2 Pathway
- #Colitis
- #Bile Acid Metabolism
- Matrine targets JAK2 directly, as shown by molecular docking.
- In colitis models, matrine reduces inflammation by lowering cytokines like IL-1β, TNF-α, and IL-6.
- Matrine decreases oxidative stress markers, including reactive oxygen species (ROS).
- It restores bile acid homeostasis by upregulating transporters MRP3 and MRP4 and receptor FXR.
- JAK2 overexpression reverses matrine's therapeutic effects, confirming JAK2-dependent mechanism.
- Findings validated in human ulcerative colitis patients, showing relevance to clinical conditions.