PCSK9 and breast cancer survival: a Mendelian Randomization study - PubMed
4 hours ago
- #breast cancer survival
- #PCSK9
- #Mendelian Randomization
- Study investigates the association between PCSK9 gene variants and breast cancer survival using Mendelian Randomization (MR).
- No significant association found between PCSK9 variants and breast cancer survival in any MR approach or replication data.
- Positive control analyses (coronary artery disease) confirmed the validity of the MR methods used.
- Discrepancies with previous findings may be due to different genetic models, sample selection criteria, or time-variability of hazard ratio estimates.
- Suggests further exploration needed before considering PCSK9 as a therapeutic target in breast cancer patients.