Common gamma chain cytokines-driven optimization of chimeric antigen receptor T cells: Mechanistic insights and future directions - PubMed
a day ago
- #Gamma chain cytokines
- #Solid tumors
- #CAR-T therapy
- CAR-T cell therapy shows efficacy in hematological malignancies but faces challenges in solid tumors due to immunosuppressive tumor microenvironment, insufficient persistence, exhaustion, and off-target toxicity.
- Gamma chain (γc) cytokines (IL-2, IL-4, IL-7, IL-9, IL-15, IL-21) regulate immune cell survival, proliferation, and differentiation via the γc-JAK1/3-STAT signaling axis.
- γc cytokines are used in CAR-T therapy to enhance in vitro expansion, in vivo persistence, effector functions, and precise cytokine release to mitigate toxicity.
- Technological strategies have evolved from recombinant protein administration to 'armored' CAR-T cells and programmable cytokine circuits for spatiotemporal control.
- The review summarizes γc cytokines' roles, research progress, and potential to improve CAR-T therapy safety and efficacy in solid tumors.