Inhibitory receptor agonists: Emerging strategies in immune modulation - PubMed
4 hours ago
- #autoimmune diseases
- #inhibitory receptors
- #immune modulation
- Inhibitory receptors (IRs) like CTLA-4, PD-1, LAG3, TIM-3, and TIGIT regulate immune homeostasis to prevent autoimmunity.
- Blocking IRs has revolutionized cancer immunotherapy by boosting antitumor T cell responses.
- Agonistic antibodies activating IRs show promise in preclinical models for treating autoimmune and inflammatory diseases by promoting immune tolerance.
- Emerging strategies focus on harnessing IR agonists to suppress pathological effector T cell functions.
- Recent progress involves developing agonistic IR-targeted therapies, with ongoing challenges in translation to clinical practice.