A Non-canonical RNA-Binding Function of NQO1 Drives Angiogenesis in Esophageal Squamous Cell Carcinoma via Extracellular Vesicle-Mediated AGRN Transfer - PubMed
4 hours ago
- #Esophageal Squamous Cell Carcinoma
- #Angiogenesis
- #NQO1
- NQO1 promotes ESCC progression and lung colonization via a non-enzymatic mechanism.
- NQO1 stabilizes AGRN mRNA, increasing AGRN expression and enhancing angiogenesis.
- AGRN interacts with FLNA to improve endothelial cytoskeletal organization.
- Panobinostat destabilizes NQO1, suppressing AGRN-dependent angiogenic signaling.
- Combination therapy with panobinostat and anlotinib shows superior tumor growth inhibition.