An Extravascular Synergistic Cocktail Therapeutic Strategy Based on Lanifibranor Loaded Self-Healing Bioelastomer for Abdominal Aortic Aneurysms - PubMed
7 hours ago
- #Lanifibranor Therapy
- #Abdominal Aortic Aneurysm
- #Self-Healing Bioelastomer
- Proposes an extravascular synergistic cocktail (ESC) therapeutic strategy for abdominal aortic aneurysms (AAA) using a self-healing bioelastomer loaded with the antifibrotic drug lanifibranor.
- The ESC combines mechanical support and vascular remodeling inhibition to treat AAA by wrapping the aorta, addressing limitations of current surgical and endovascular methods.
- Single-cell RNA-sequencing shows adventitial fibroblasts (AFs) undergo myogenic transformation in AAA, releasing chemokines like MCP-1, with lanifibranor maintaining AF phenotype by promoting lipid metabolism.
- The bioelastomer features arterial-like mechanical properties and ultra-fast self-healing under blood conditions, enabling rapid in situ application in both rat and dog AAA models.
- Demonstrates feasibility of minimally invasive laparoscopic implantation in pigs, highlighting potential for clinical translation and application.