An Fc-silent OspA monoclonal antibody passively protects mice from tick and intradermal Borrelia burgdorferi challenge - PubMed
7 hours ago
- #vaccine research
- #Lyme disease
- #monoclonal antibody
- The monoclonal antibody LA-2 is crucial for OspA-based Lyme disease vaccines.
- An Fc-silent version of LA-2 (LA-2 LALAPG) was created to study its protective mechanisms.
- LA-2 LALAPG retained OspA binding but had reduced complement-dependent activities.
- Both LA-2 and LA-2 LALAPG equally protected mice against Borrelia burgdorferi challenges.
- LA-2's primary protective mechanism involves direct interaction with spirochetes, not complement-dependent killing.
- Findings may help understand OspA-based vaccine immunity in humans.