Association between the C-reactive protein-triglyceride glucose index and incident sarcopenia in middle-aged and elderly Chinese: A prospective nationwide cohort study in China - PubMed
a day ago
- #sarcopenia
- #elderly health
- #CTI
- The study explores the association between the C-reactive protein-triglyceride glucose index (CTI) and incident sarcopenia in middle-aged and elderly Chinese.
- Data from the China Health and Retirement Longitudinal Study (CHARLS) was used, involving 5741 participants aged ≥45 years with baseline (2011) and follow-up (2015) data.
- CTI was calculated as 0.412 × Ln (C-reactive protein) + [Ln (Triglyceride × Fasting plasma glucose)]/2.
- Sarcopenia was defined using the 2019 Asian Working Group for Sarcopenia criteria, considering muscle strength, appendicular skeletal muscle mass, and physical performance.
- Higher CTI levels were inversely correlated with sarcopenia risk, with an unadjusted OR of 0.643 and a fully adjusted OR of 0.732.
- Quartile analysis showed a progressive reduction in risk from Q1 to Q4 (Q4 OR = 0.618).
- Propensity score matching and inverse probability weighting confirmed the robustness of the results.
- Restricted cubic splines indicated a non-linear association (P for non-linearity = 0.011).
- Subgroup analyses identified effect modifications by sex, marital status, and arthritis.
- The study found a U-shaped association between CTI and sarcopenia risk, with both low and high CTI levels being detrimental.
- The association was particularly apparent in women and older adults, suggesting the need for further research into underlying mechanisms.