Circulating gut microbial metabolites and risk of coronary heart disease: A prospective multi-stage metabolomics study - PubMed
5 hours ago
- #metabolomics
- #gut microbiota
- #coronary heart disease
- Study links circulating gut microbial metabolites to coronary heart disease (CHD) risk.
- Multi-stage metabolomics study involving five prospective cohorts with diverse populations.
- Discovery stage identified 73 microbiota-related metabolites associated with CHD.
- 24 metabolites validated in-silico, with five significantly associated with CHD in targeted assay.
- Key metabolites include imidazole propionate, 3-hydroxy-2-ethylpropionate, and trimethylamine N-oxide.
- Associations consistent across demographics but some variations by race, age, and obesity status.
- Findings highlight gut microbial metabolism's role in CHD development and potential therapeutic targets.