AURKA-mediated destabilization of SAPS3 drives ferroptosis evasion via 7-dehydrocholesterol biosynthesis in colorectal cancer - PubMed
3 hours ago
- #AURKA
- #colorectal cancer
- #ferroptosis
- AURKA destabilizes SAPS3, leading to ferroptosis evasion in colorectal cancer (CRC).
- AURKA-mediated phosphorylation of SAPS3 activates AMPK, inhibiting SREBP2 and DHCR7, resulting in 7-dehydrocholesterol (7-DHC) accumulation.
- 7-DHC acts as a lipid antioxidant, conferring resistance to ferroptosis.
- Inhibition of AURKA restores ferroptosis sensitivity and enhances chemotherapy efficacy in CRC models.
- High AURKA expression correlates with poor prognosis and reduced chemotherapy response in CRC patients.
- The study identifies the AURKA-SAPS3-AMPK-SREBP2 axis as a key regulator linking cholesterol metabolism to ferroptosis evasion.