B and T cell responses to pre-erythrocytic R21/Matrix-M and blood-stage RH5.1/Matrix-M malaria vaccines in endemic settings - PubMed
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- #B cell responses
- #malaria vaccines
- #T cell responses
- Study focuses on B and T cell responses to R21/Matrix-M and RH5.1/Matrix-M malaria vaccines in endemic settings.
- Higher NANP-specific memory B cell responses in infants vs. adults with R21/Matrix-M, and with higher adjuvant dose (50μg vs. 25μg).
- For RH5.1, delayed booster dosing (0-1-6 months) showed greater memory B cell responses compared to monthly or delayed fractional regimens.
- Previous malaria exposure linked to increased RH5-specific cTfh and cTfh2 cell frequencies.
- NANP-specific B cells and total cTfh cells correlated with anti-NANP serum IgG levels.
- RH5-specific B cell responses correlated with peak and late time point serum antibody levels (2-years post-vaccination).
- Age, adjuvant dose, vaccine dose, and booster timing impact antigen-specific cellular responses.
- Findings could inform next-generation multi-stage malaria vaccination strategies.