Exploring multiple drug actions of a Ca2+-sensing receptor modulator: perspectives in alternative applications of cinacalcet - PubMed
3 hours ago
- #Drug Repurposing
- #CaSR Modulator
- #Cinacalcet
- Cinacalcet is a Ca2+-sensing receptor (CaSR) modulator used clinically to reduce parathyroid hormone (PTH) secretion and lower serum Ca2+ levels in conditions like secondary hyperparathyroidism and hypercalcemia.
- Experimental studies show cinacalcet has diverse potential applications beyond its original use, including treating diarrhea, cancer, kidney problems, and providing antibacterial, cardioprotective, and neuroprotective effects.
- Some of cinacalcet's effects are CaSR-dependent, while others operate through CaSR-independent mechanisms, highlighting its versatile pharmacological profile.
- The review discusses precautions and protocols for repurposing cinacalcet, emphasizing its promising therapeutic prospects.