OMICmAge quantifies biological age by integrating multi-omics with electronic medical records - PubMed
5 hours ago
- #biomarkers
- #multi-omics
- #biological aging
- OMICmAge quantifies biological age by integrating multi-omics with electronic medical records.
- Developed EMRAge, a biomarker of mortality risk, using clinical lab data from ~31,000 participants.
- DNAmEMRAge and OMICmAge were modeled using elastic net regression with DNA methylation and multi-omics.
- Both biomarkers strongly associate with chronic diseases and mortality, performing comparably or better than current biomarkers.
- OMICmAge integrates proteomic, metabolomic, and clinical domains while being quantifiable from DNA methylation alone.
- The framework provides an accessible, scalable measure of biological aging with potential to reveal healthspan and disease risk connections.
- The study involved multiple cohorts including Massachusetts General Brigham Aging Biobank, TruDiagnostic, and Generation Scotland.
- Several authors have filed patents related to the work, and some have affiliations with TruDiagnostic.