Chlorogenic acid promotes liver regeneration after partial hepatectomy through activating Nrf2 via directly targeting Keap1 - PubMed
3 hours ago
- #Nrf2 activation
- #liver regeneration
- #chlorogenic acid
- Chlorogenic acid (CGA) promotes liver regeneration (LR) after partial hepatectomy (PHx).
- CGA activates Nrf2 by directly targeting Keap1, which is crucial for LR.
- Nrf2 activation by CGA upregulates E2F1 to accelerate cell cycle progression.
- Nrf2 also increases PGC-1α expression, enhancing ATP production to support LR.
- The Arg415 residue in Keap1's kelch domain is essential for CGA binding.
- Nrf2's role in LR was confirmed using knockout and liver-specific Keap1 depletion models.
- CGA is a promising therapeutic candidate for enhancing liver regeneration.