Gut Luminal Exosomes in Young and Old Mice: Multi-Omic Characteristics and Regulation of Gut Permeability - PubMed
3 hours ago
- #exosomes
- #aging
- #gut microbiome
- Aging impacts physiological functions, including metabolism, and this study focuses on luminal fecal exosomes (LFEs) in mice.
- LFEs from old mice (24-month) differed in proteomic and miRNA cargos compared to young mice (3-month), showing distinct age-related profiles.
- Transfer of LFEs from old mice to young mice impaired gut barrier integrity and metabolic function, while young LFEs improved conditions in old mice.
- Multi-omics analysis linked old LFEs to insulin resistance and barrier dysfunction pathways, influencing cancer, neurobehavior, and metabolism.
- LFEs are identified as age-dependent mediators in microbiome-host communication, contributing to intestinal barrier dysfunction and metabolic decline.