Neuro-tumor interactions in peripheral tumors - PubMed
3 hours ago
- #tumor microenvironment
- #neuro-tumor interactions
- #therapeutic strategies
- The nervous system is now recognized as an active driver in the tumor microenvironment (TME), not just a passive bystander.
- The review differentiates between passive perineural invasion (PNI) and active tumor innervation, defining the 'neural niche'.
- Sympathetic signaling drives an 'angio-metabolic switch' and immune evasion, while parasympathetic inputs control stemness and inflammation context-dependently.
- Sensory neurons play an underappreciated role in promoting T-cell exhaustion via neuropeptides like calcitonin gene-related peptide (CGRP).
- Therapeutic strategies targeting neuro-tumor crosstalk include repurposing β-blockers and deploying nanotechnologies to overcome therapeutic resistance and restore anti-tumor immunity.