Forkhead box protein M1 network induction and crosstalk drives the development of alcohol-associated liver disease - PubMed
4 hours ago
- #FOXM1
- #liver disease
- #alcohol-associated liver disease
- FOXM1 is upregulated in both mouse and human alcohol-associated liver disease (ALD), especially in hepatocytes.
- Ethanol increases FOXM1 activation via interactions with PIN1, boosted by PKCε, MEK/ERK, and cyclin D1-CDK4/6 pathways.
- Inhibiting FOXM1 with FDI-6 or knocking it out in hepatocytes protects mice from ethanol-induced liver injury, triglyceride buildup, and inflammation.
- RNA-Seq identifies new FOXM1 targets like granulin and cathepsins, which help in PIN1 nuclear translocation, enhancing FOXM1 activation.
- Targeting the FOXM1 pathway may offer a new therapeutic approach for treating ALD.