Resistance Mechanisms and Molecular Epidemiology of Neisseria gonorrhoeae with Low Susceptibility/Resistance to Azithromycin or Cephalosporins - PubMed
4 hours ago
- #Antimicrobial Resistance
- #Molecular Epidemiology
- #Neisseria gonorrhoeae
- Study investigates resistance patterns of Neisseria gonorrhoeae to azithromycin and ceftriaxone in Wenzhou (2021-2023).
- 212 isolates tested; 12.74% showed azithromycin resistance, 3.77% had low susceptibility/resistance to ceftriaxone.
- High PPNG (81.48%) and TRNG (33.33%) rates among azithromycin-resistant strains.
- NG-MAST typing revealed dominant genotypes: ST5061, ST1866, ST4183, ST14504, ST9659, ST12196 for azithromycin-resistant strains; ST1866 for ceftriaxone-resistant strains.
- First detection of dual azithromycin/ceftriaxone-resistant strain in the region.
- Findings support rational antibiotic use and resistance surveillance, especially in young/middle-aged adults.