C-Reactive Protein-Triglyceride-Glucose Index and Coronary Artery Calcium Progression: A Prospective Cohort Analysis - PubMed
3 hours ago
- #inflammation
- #biomarker
- #cardiovascular disease
- The C-reactive protein-triglyceride-glucose index (CTI) reflects systemic inflammation and insulin resistance, and this study investigates its link to coronary artery calcium (CAC) progression.
- In a prospective cohort from the CARDIA study, CTI was calculated at year 15 and categorized into quartiles, with CAC measured over time and progression defined based on baseline levels.
- Among 2655 participants, those in the highest CTI quartile had a 38% higher risk of CAC progression compared to the lowest quartile, with consistent findings across subgroups and robust after adjustments.
- Higher CTI was independently associated with increased CAC progression, suggesting its potential as a biomarker for identifying individuals at elevated risk of subclinical atherosclerosis.