Mapping ADHD Heterogeneity and Biotypes by Topological Deviations in Morphometric Similarity Networks - PubMed

4 hours ago

ADHD is characterized by clinical heterogeneity, requiring neurobiologically informed subtyping approaches.
Normative modeling of topological properties from brain morphometry similarity networks was used to stratify children with ADHD.
Three topological metrics were analyzed: degree centrality, nodal efficiency, and participation coefficient.
Three distinct ADHD biotypes were identified: severe-combined with emotional dysregulation, predominantly hyperactive/impulsive, and predominantly inattentive.
Each biotype showed unique clinical profiles, longitudinal trajectories, and distinct neurochemical and functional correlates.
The findings were validated in an independent cohort, demonstrating robust generalizability.
The study advances understanding of ADHD's neurobiological complexity and supports personalized management approaches.

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