CSF Proteins Associated With Neuroaxonal Damage in Early Active Multiple Sclerosis - PubMed
3 hours ago
- #Multiple Sclerosis
- #Neuroaxonal Damage
- #CSF Proteins
- Proximity extension assay used to analyze proteins in CSF and serum samples from early-stage, treatment-naïve MS patients (n=114) stratified by CSF neurofilament light (NfL) levels.
- Thirteen CSF proteins were upregulated in the discovery cohort; six (CCL19, CXCL11, MSR1, CXCL10, TNFRSF12A, CCL23) were replicated in a validation cohort (n=128) of clinically diverse MS patients.
- Seventy-five CSF proteins showed a positive linear association with CSF-NfL, while no consistent protein patterns linked to serum-NfL were observed.
- Replicated CSF proteins indicate distinct inflammatory processes associated with ongoing neuroaxonal degeneration in MS.
- No conflicts of interest directly related to this study's findings were reported; authors disclosed various grants and fees from pharmaceutical companies.