Exploring the molecular mechanism of Qingzao Decoction in the treatment of IgA vasculitis through network pharmacology and molecular docking - PubMed
5 days ago
- #network pharmacology
- #IgA vasculitis
- #Qingzao Decoction
- Qingzao Decoction's mechanism in treating IgA vasculitis (IgAV) was explored using network pharmacology and molecular docking.
- Active compounds and targets of Qingzao Decoction were identified from TCMSP and HERB databases.
- IgAV-related target genes were sourced from GeneCards and OMIM databases.
- A protein-protein interaction network was constructed using STRING and Cytoscape, identifying core targets like STAT3, MAPK1, ESR1, IL6, FOS, TP53, TNF, and IL1B.
- Gene ontology and KEGG pathway analyses revealed 2539 entries and 182 pathways, including AGE-RAGE, IL-17, TNF, HIF-1, and PI3K-Akt signaling pathways.
- Key herbs in Qingzao Decoction, such as Huangqi, Gancao, Huangbai, and Chaihu, play significant roles in treating IgAV.
- The decoction may treat IgAV through multi-pathway and multi-target effects, influencing inflammation, immune regulation, apoptosis, and cell proliferation.