Recent Advances in Flavonoids and Chronic Disease: Mechanisms, Therapeutic Applications, and Future Directions - PubMed
4 hours ago
- #Therapeutic Applications
- #Chronic Disease
- #Flavonoids
- Flavonoids are polyphenolic compounds found in fruits, vegetables, tea, and medicinal plants.
- They exhibit antioxidant, anti-inflammatory, neuroprotective, and anticancer properties.
- Key benefits include roles in aging, neuroprotection, cardiovascular health, metabolic regulation, and cancer therapy.
- Flavonoids modulate signaling pathways like NF-κB, Nrf2, PI3K/Akt, MAPK, and Wnt/β-catenin.
- They reduce oxidative stress, enhance mitochondrial function, regulate autophagy, and modulate immune responses.
- Flavonoids improve chemotherapy sensitivity, inhibit tumor metastasis, and suppress angiogenesis.
- Challenges include poor bioavailability and metabolic variability, requiring advanced delivery systems.
- Future research should focus on nanotechnology, personalized medicine, and large-scale clinical trials.