Intracranial Hemorrhage Patterns and Outcomes in Minor Stroke: Analysis of the TEMPO-2 Trial - PubMed
6 hours ago
- #Minor Stroke
- #TEMPO-2 Trial
- #Intracranial Hemorrhage
- Any intracranial hemorrhage (ICH) occurred in 11.8% of minor stroke patients, with higher rates in tenecteplase vs. standard care (14.4% vs. 9.2%).
- The presence of any ICH was not linked to reduced odds of returning to baseline neurological function but was strongly associated with higher 90-day mortality (adjusted hazard ratio: 3.71).
- Symptomatic ICH rates were not significantly different between treatment arms, although numerically higher in the tenecteplase group.
- Most hemorrhages were minor petechial transformations, emphasizing that even minor hemorrhagic transformations can be prognostically significant in minor ischemic stroke.
- Predictors for ICH included premorbid hypertension and atrial fibrillation, with patients having any ICH being older and more frequently female.