Cerebral collateral arteriogenesis and cerebrovascular reserve in aged and diet-induced obese mice after unilateral common carotid occlusion - PubMed
7 hours ago
- #cerebrovascular reserve
- #aging
- #arteriogenesis
- The study investigated the effects of aging and diet-induced obesity on cerebral collateral arteriogenesis and cerebrovascular reserve after right common carotid artery occlusion (RCCAO) in mice.
- Young mice showed significant arteriogenesis in the circle of Willis (COW) and pial collaterals post-RCCAO, leading to full recovery of baseline cerebral blood flow (CBF).
- Aging progressively reduced arteriogenesis, resulting in partial or no CBF recovery in aging and aged mice, respectively.
- Cerebrovascular reserve was found to diminish with advancing age.
- Diet-induced obesity had milder effects on arteriogenesis compared to aging.
- The study highlights that cerebral collateral arteriogenesis is crucial for cerebrovascular reserve post-arterial occlusion and declines with age.