An Exploratory Study on the Pathogenic Role of Faecal Extracellular Vesicles in Metabolic Dysfunction-Associated Steatotic Liver Disease Progression and in Drug-Induced Liver Injury - PubMed
3 hours ago
- #microbiome
- #liver disease
- #extracellular vesicles
- Study explores the role of faecal extracellular vesicles (fEVs) in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) and Drug-Induced Liver Injury (DILI).
- DILI patients showed distinct microbiome profiles in fEVs, with decreases in Paraprevotella and increases in AAP99, Acinetobacter, Actinobacillus, Aerococcus, and Anaeroglobus.
- Higher levels of 16S rDNA were found in plasma EVs from MASLD and DILI patients.
- Treatment with DILI and MASLD F3 fEVs increased TLR4, TLR5, IL6, and CASP3 expression, leading to lipid droplet accumulation in HepG2 cells.
- DILI fEVs enhanced the hepatotoxic effects of diclofenac, increasing inflammation, lipid accumulation, and mitochondrial dysfunction.
- Findings suggest bacterial EVs enter the bloodstream and modulate immune responses, contributing to liver disease progression.