Spatial transcriptomics maps early B-cell and T-cell activation in hidradenitis suppurativa - PubMed
9 hours ago
- #hidradenitis suppurativa
- #B-cell activation
- #spatial transcriptomics
- Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease that progresses from nodules to dermal tunnels and fibrosis.
- Spatial transcriptomics reveals early immune activation in HS, including B-cell enrichment and T17 pathway activation, before tunnel or TLS formation.
- Single-cell RNA sequencing shows early plasma cell expansion and multifunctional B-cells expressing pro-inflammatory cytokines.
- T-cells, not fibroblasts, are the main producers of the B-cell chemoattractant CXCL13 in early lesions.
- Early therapeutic targeting of T17 axis and B-cell-mediated inflammation may prevent disease progression.