A reciprocal glial circuit calibrates injury information and governs the tissue response balance - PubMed
3 hours ago
- #brain injury
- #glial circuit
- #ATP signaling
- Acute brain injury triggers focal extracellular ATP events called Inflares, which have specific spatiotemporal signatures and scale with injury severity.
- Microglia provide negative feedback on Inflares by adjusting interleukin (IL)-1β output based on ATP levels and cellular state.
- Astrocytes receive the IL-1β signal via IL-1R1 and Ca2+-calcineurin signaling, integrating it with injury input to regulate Panx1-dependent ATP release.
- These bidirectional interactions form a reciprocal glial circuit that maintains a balanced injury response.
- Disrupting this circuit destabilizes the dynamic control, impairing cellular reactivity and worsening early injury outcomes.