Early Steroid and Anakinra Use to Manage Axicabtagene Ciloleucel Toxicity Reduces the Total Duration of CRS and ICANS - PubMed
5 hours ago
- #CRS and ICANS
- #CAR-T therapy
- #toxicity management
- Early steroid and anakinra use reduces duration of CRS and ICANS in axi-cel therapy.
- Modified protocol showed lower severe ICANS rates without increased steroid doses.
- Similar efficacy outcomes and hospitalization lengths between pre- and post-change cohorts.
- Anakinra is a safe and effective alternative to tocilizumab for toxicity management.