Gut microbiota and pattern recognition receptors in polycystic ovary syndrome - PubMed
3 hours ago
- #gut microbiota
- #polycystic ovary syndrome
- #pattern recognition receptors
- PCOS is recognized as a disorder of impaired immune-endocrine homeostasis.
- Gut dysbiosis and microbial metabolite imbalance activate pattern recognition receptors (PRRs), forming a PRR-microbiota-reproductive axis.
- Gut-derived signals like LPS and SCFAs modulate TLR, NLR, and RLR pathways, disrupting immune regulation.
- The Reproductive Immune Tolerance Disruption Theory proposes chronic PRR activation shifts reproductive immunity to a low-grade inflammatory state.
- This inflammation promotes hyperandrogenism, anovulation, insulin resistance, and metabolic dysfunction in PCOS.
- Multi-omics studies clarify crosstalk between gut microbial signatures and innate immune signaling.
- Potential therapies include PRR-selective immunomodulation, microbiota-based treatments, and epigenetic metabolic interventions.
- Understanding PRR-driven immunomodulation helps reconcile endocrine, metabolic, and reproductive abnormalities in PCOS.