Immunometabolism in rheumatoid arthritis: mechanisms, biomarkers, and the path to precision medicine - PubMed
4 hours ago
- #immunometabolism
- #precision-medicine
- #rheumatoid-arthritis
- Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by synovitis and joint degeneration.
- Immunometabolic dysregulation in RA involves metabolic reprogramming of immune and stromal cells affecting glycolysis, oxidative phosphorylation, and lipid metabolism.
- The review focuses on immunometabolic dysregulation in T cells, macrophages, B cells, and fibroblast-like synoviocytes in RA.
- High-dimensional biomarkers like metabolomic, transcriptomic, and proteomic signatures can help stratify patients and predict treatment responses.
- Treatment approaches targeting immunometabolic pathways include metabolic inhibitors and drug repurposing (e.g., metformin).
- The review proposes integrating immunometabolic profiling into precision medicine for more personalized RA treatment.