MFN2-PERK Axis Regulates ER Stress in Parotid Glands of Aged Mice via MAMs - PubMed
3 hours ago
- #ER stress
- #aging
- #MAMs
- Aging impairs parotid gland morphology and function, with unknown mechanisms.
- Mitochondria-associated membranes (MAMs) integrity decreases in aged mice, affecting ER-mitochondria connections.
- PERK signaling, key in ER stress, is activated in the parotid glands of aged mice.
- Aging downregulates MFN2, disrupting mitochondrial dynamics and reducing MAMs function via blocked MFN2-PERK interaction.
- Treatment with 4-PBA or GSK2606414 improves MAMs integrity, inhibits PERK pathway, and reduces apoptosis.