Polyphenol mediated zinc-oxygen synergistic hydrogel remodels senescent microenvironment for periodontal tissue regeneration - PubMed
3 days ago
- #hydrogel
- #periodontal regeneration
- #senescence
- Polyphenol-mediated zinc-oxygen synergistic hydrogel targets senescent periodontal microenvironment.
- Hydrogel incorporates Mn/HCA-modified calcium peroxide and HCA-modified zeolitic imidazolate framework-8.
- Strategy reduces oxidative stress, corrects hypoxia, and restores microbial balance.
- Alleviates telomere shortening, DNA damage, and oxidative stress in stem cells.
- Offers potential treatment for periodontitis and aging-associated inflammatory diseases.