A spinal USP7-Bach1 positive feedback loop drives NOX4-mediated ferroptosis in neuropathic pain - PubMed
3 hours ago
- #Oxidative Stress
- #Ferroptosis
- #Neuropathic Pain
- Bach1 is a key regulator of ferroptosis in the spinal cord during neuropathic pain, with its expression upregulated after peripheral nerve injury.
- Bach1 directly binds to the NOX4 promoter, enhancing its transcription, which leads to excessive ROS generation and lipid peroxidation.
- USP7 interacts with Bach1, promoting its stability through deubiquitination, while Bach1 transcriptionally upregulates USP7, forming a positive feedback loop.
- The USP7-Bach1-NOX4 axis drives ferroptosis and redox dysregulation, contributing to persistent pain hypersensitivity in neuropathic pain.
- Inhibition of the USP7-Bach1-NOX4 signaling attenuates ferroptosis and alleviates neuropathic pain, identifying potential therapeutic targets.