Microbiota-mediated induction of beige adipocytes in response to dietary cues - PubMed
3 hours ago
- #diet
- #microbiota
- #adipose tissue
- Microbiota-mediated induction of beige adipocytes is influenced by dietary protein availability.
- Low-protein diets (LPDs) induce browning of white adipose tissue (WAT) similarly to cold exposure or β-adrenergic receptor activation.
- Germ-free mice show diminished LPD-mediated browning, which can be restored by colonization with specific bacterial consortia.
- Microbiota-induced browning involves bile acids activating the farnesoid X receptor (FXR) in adipose progenitor cells.
- Commensal-derived ammonia (via nrfA gene) drives fibroblast growth factor 21 (FGF21) expression in hepatocytes, contributing to WAT browning.
- Both the bile acid-FXR and ammonia-FGF21 pathways are essential and non-redundant in promoting WAT browning.
- The study reveals a link between diet, gut microbiota, and adipose tissue remodelling.