The amino acid transporter LAT1 coordinates proper motor function at the perinatal stage - PubMed
4 hours ago
- #motor neurons
- #spinal muscular atrophy
- #LAT1
- LAT1 (L-type amino acid transporter 1) is crucial for motor function development in the perinatal stage.
- Mice lacking Slc7a5 (LAT1 gene) in Syn1-expressing neurons showed motor coordination deficits and early lethality.
- Deficits included spinal motor neuron degeneration, gliosis, muscle atrophy, and NMJ maldevelopment.
- Apoptosis inhibition prolonged survival and reduced motor neuron loss in Slc7a5-deficient mice.
- LAT1 dysfunction is linked to spinal muscular atrophy, suggesting a therapeutic target for motor neuron diseases.