Global epidemiology of ovarian cancer: patterns, trends, and risk factors - PubMed
6 hours ago
- #Risk Factors
- #Epidemiology
- #Ovarian Cancer
- Ovarian cancer ranked eighth among frequently diagnosed cancers in women globally in 2022.
- Global age-standardized incidence rates decreased from 7.22 to 6.71 per 100,000 between 1990 and 2021.
- Incidence trends varied by country: declining in high-income nations but increasing in Africa and parts of Asia like Japan and India.
- Global age-standardized mortality rates decreased from 4.73 to 4.06 per 100,000 between 1999 and 2021.
- Age-standardized 5-year net survival rates remain below 50% in most countries.
- Key risk factors include reproductive factors, oral contraceptives, diet, endometriosis, pelvic inflammatory disease, obesity, diabetes, and asbestos exposure.
- No effective screening or prevention strategies exist for average-risk populations without family history or genetic mutations.
- Risk-reducing salpingo-oophorectomy is the gold standard for high-risk individuals with hereditary mutations.