Maternal Exposure to Bisphenol A Bis(diphenyl Phosphate) Induces Offspring Colitis through Disrupting the Gut Microbiome-Metabolite Axis - PubMed
3 hours ago
- #Bisphenol A
- #Colitis
- #Gut Microbiome
- Maternal exposure to Bisphenol A bis(diphenyl phosphate) (BDP) during pregnancy triggers colonic inflammation and gut microbiome dysbiosis in offspring.
- BDP crosses the placental barrier, and maternal microbiome transmission is the primary source (>70%) of offspring gut microbiome.
- Exposure leads to microbial changes like Streptococcus enrichment and Bifidobacterium depletion, reducing microbial diversity.
- Metabolite analysis shows positive correlations of butyrate and negative correlations of propionate with proinflammatory cytokines.
- In vitro experiments confirm these correlations, demonstrating a transgenerational mechanism via the gut microbiome-metabolite axis.