Pien Tze Huang ameliorates alcohol-associated liver disease via suppressing oxidative stress and ferroptosis - PubMed
3 hours ago
- #Ferroptosis
- #Alcoholic Liver Disease
- #Traditional Chinese Medicine
- Pien Tze Huang (PTH) significantly improves alcohol-associated liver disease (ALD) in mice.
- PTH's therapeutic effect is achieved by suppressing oxidative stress and ferroptosis, not by enhancing alcohol metabolism.
- Active components in PTH are identified as bovinic acid and taurine, derived from Calculus Bovis and Musk.
- These components bind to SIRT1, restoring the Keap1-Nrf2 signaling pathway to reduce oxidative stress and inhibiting transferrin receptor to prevent ferroptosis.