Independent Testing of Published CT Models for PD-L1 Status in Non-Small Cell Lung Cancer - PubMed
4 hours ago
- #CT radiomics
- #PD-L1 prediction
- #NSCLC
- The study performed independent testing of published CT radiomic models to predict PD-L1 status in non-small cell lung cancer (NSCLC) patients using a multi-institutional external test set.
- Out of 17 identified models from literature, only three (18%) could be reconstructed from published details; model performance in external testing was generally lower than originally reported.
- Model 3 showed comparable discrimination for PD-L1 TPS≥50% (AUC 0.61 vs published 0.66), while models 1 and 2 had significantly lower AUCs in testing compared to their published results.
- A CT model retrained to predict CD274 mRNA expression (model 3a) correlated with PD-L1 TPS and discriminated both TPS≥1% and TPS≥50% thresholds, with AUCs of 0.61 and 0.66 respectively.
- The findings suggest CT models can discriminate PD-L1 expression at clinical thresholds in resectable NSCLC, but predictive performance in independent validation is often reduced, highlighting the need for rigorous external testing.