Genetically engineered Escherichia coli Nissle 1917 enabling on-site melanin synthesis attenuates radiation enteritis through ferroptosis inhibition and gut microbiota modulation - PubMed
7 hours ago
- #radiation enteritis
- #engineered probiotics
- #ferroptosis inhibition
- Engineered E. coli Nissle 1917 with tyrosinase (EcN-Tyr) synthesizes melanin on-site for radiation protection.
- EcN-Tyr is encapsulated in alginate-chitosan microspheres (EcN-Tyr (A/C)1) for oral delivery, resisting gastric acid and targeting intestinal inflammation.
- Treatment inhibits ferroptosis by reducing lipid peroxidation, alleviating radiation-induced intestinal inflammation and DNA damage.
- It modulates gut microbiota, increasing beneficial bacteria like Akkermansia and Ligilactobacillus while reducing harmful Escherichia-Shigella.
- Shows potential as a novel probiotic carrier for radiation enteritis, leveraging natural biomaterials for therapeutic innovation.