LILRB4 shapes an immunosuppressive microenvironment to drive cervical cancer progression through tumor-infiltrating myeloid cell expansion and CD8+ T-cell suppression - PubMed
9 hours ago
- #immunosuppression
- #cervical cancer
- #LILRB4
- LILRB4 is upregulated in cervical cancer (CC) tissues and associated with advanced disease and immunosuppressive genes.
- Blocking LILRB4 reduces tumor growth and decreases CD8+ T-cell exhaustion in CC.
- LILRB4 blockade reduces tumor-infiltrating myeloid cells (TIMs), including MDSCs and M2-TAMs.
- HPV16 upregulates ApoE, which mediates CD8+ T-cell suppression via LILRB4.
- The HPV16/ApoE/LILRB4 axis creates an immunosuppressive microenvironment, promoting CC progression.