Tetraspanin 7-mediated endothelial migrasomes unveil a novel mechanism of angiogenesis through the PI3K/AKT pathway in diabetic wound healing - PubMed
10 hours ago
- #Angiogenesis
- #PI3K/AKT Pathway
- #Diabetic Wound Healing
- The study explores Tetraspanin 7 (TSPAN7) as a key migrasome-related gene in diabetic foot ulcer (DFU) healing.
- TSPAN7 is downregulated in DFU endothelial cells; its overexpression enhances migrasome formation via the PI3K/AKT pathway.
- TSPAN7 overexpression promotes endothelial proliferation, migration, and VEGF upregulation in vitro.
- In diabetic mice, endothelial-specific Tspan7 overexpression accelerates wound healing, improves re-epithelialization, collagen deposition, and angiogenesis.
- TSPAN7-mediated migrasomes represent a novel therapeutic target for diabetic wound healing by restoring PI3K/AKT signaling.