Exercise alleviates cognitive dysfunction in Alzheimer's disease mice via skeletal muscle-derived extracellular vesicles that enhance plaque clearance by microglia - PubMed
4 hours ago
- #Alzheimer's disease
- #Exercise
- #Extracellular vesicles
- Exercise improves cognitive function in Alzheimer's disease (AD) mice.
- Skeletal muscle-derived extracellular vesicles (SKM-EVs) play a key role in this improvement.
- SKM-EVs are taken up by microglia, enhancing amyloid-beta plaque clearance.
- miR-378a-3p in SKM-EVs regulates lipid metabolism in microglia by targeting p110α.
- Administering EVs from miR-378a-overexpressing myotubes alleviates cognitive impairment in AD mice.
- Exercise-induced SKM-EVs act as a myokine, facilitating muscle-to-brain communication.
- This study suggests a potential exercise-mimicking therapeutic strategy for AD.