Skeletal muscle reprogramming in peripheral nerve injury: mechanisms, therapeutic roles, and complication management - PubMed
3 hours ago
- #regenerative medicine
- #peripheral nerve injury
- #skeletal muscle reprogramming
- Peripheral nerve injury (PNI) leads to long-term neuromuscular dysfunction, muscle atrophy, fibrosis, and chronic pain.
- Skeletal muscle reprogramming is a promising strategy to enhance regenerative outcomes by modulating cellular fate, function, or metabolic state in muscle-resident cells.
- Reprogramming strategies can mitigate denervation-induced muscle atrophy, delay fibrotic remodeling, promote neuromuscular junction (NMJ) reconstruction, and stimulate endogenous nerve regrowth.
- Key signaling pathways involved include Wnt/β-catenin, TGF-β, Notch, and HDAC-regulated chromatin dynamics.
- Innovations in small molecule cocktails, CRISPR-based transcriptional reactivation, and metabolic rewiring have expanded therapeutic tools for muscle preservation and regeneration.
- Muscle-targeted interventions can improve nerve repair efficacy and address complications of denervation when integrated with nerve-centric strategies.