FomA-Containing Outer Membrane Vesicles of Fusobacterium Nucleatum Facilitate Bladder Cancer Lymphatic Metastasis via IL-6-Dependent M2b Macrophage Polarization - PubMed
8 days ago
- #Fusobacterium nucleatum
- #lymphatic metastasis
- #bladder cancer
- Fusobacterium nucleatum (F. nucleatum) is identified as a predominant member of the urinary microbiota in bladder cancer (BCa).
- Proteomic analysis reveals FomA as the most abundant protein in F. nucleatum outer membrane vesicles (OMVs).
- FomA-containing OMVs engage Toll-like receptor 2 (TLR2), activating the NF-κB pathway and upregulating IL-6 expression.
- Elevated IL-6 induces M2b macrophage polarization, promoting VEGF-C release and facilitating lymph node (LN) metastasis in BCa.
- Pinocembrin, a natural flavonoid, is identified as an inhibitor of the FomA-TLR2 interaction, suppressing BCa progression.
- The study highlights FomA as a potential therapeutic target for preventing BCa lymphatic metastasis.