Parenteral treprostinil in paediatric pulmonary arterial hypertension: a systematic review and meta-analysis - PubMed
3 hours ago
- #Pediatric Pulmonary Arterial Hypertension
- #Treprostinil
- #Meta-Analysis
- Pediatric pulmonary arterial hypertension (PAH) is more complex and challenging to treat than adult PAH.
- Current treatment recommendations rely on expert opinion, small studies, and adult guidelines, with limited evidence for parenteral prostacyclins.
- This systematic review and meta-analysis evaluated the efficacy and safety of parenteral treprostinil in pediatric PAH.
- 32 studies with 766 pediatric patients on parenteral prostacyclins were identified, including 649 on treprostinil.
- A meta-analysis of five publications (143 treprostinil-naïve patients) showed statistically significant benefits for PAH-relevant efficacy endpoints.
- Parenteral treprostinil is concluded to be effective and safe for treating pediatric PAH based on available data.